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Interesting that Lexapro was approved for adolescents given that Celexa wasn't approved for pediatric use. Evidence suggests an imbalance of serotonin, a natural substance in the brain believed to influence mood. To Lexapro between men and women. Escitalopram helps to restore the brain's chemical balance by increasing the amount of serotonin, Escitalopram improves symptoms of depression. Interesting that Lexapro was approved for adolescents given that Celexa wasn't approved for pediatric use. Because Escitalopram appears to work by increasing the available supply of serotonin, a chemical messenger in the brain that may become unbalanced and cause depression or anxiety. In the brain that may become unbalanced and cause depression or anxiety. Lexapro affects chemicals in the brain believed to influence mood.