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By stomach acid or infection. Nexium is used to treat the infection that causes ulcers occurring just beyond the exit from the stomach. Nexium is usually taken once a day at least one hour before meals and at the same time every day. Nexium is usually taken once a day at least one hour before a meal. Esomeprazole prevents symptoms and damage to the gastrointestinal tract caused by stomach acid or infection. There are no restrictions on food, beverages, or activities while taking Nexium, unless otherwise directed by your doctor. The new medicine. The exit from the stomach. Nexium is usually taken once a day at least one hour before a meal.